The following is a list of clinical trials, most double-blinded and placebo-controlled, recorded at the National Medical Library, MEDLINE, as abstracted by GreenMedInfo for butterbur:
1. Butterbur confers complementary anti-inflammatory activity in atopic asthmatic patients maintained on corticosteroids.
2. Butterbur exhibits protection against chemically-induced nasal responsiveness in seasonal allergic rhinitis.
3. Butterbur has significant therapeutic value for the prevention of migraine in children and adolescents.
4. Butterbur is a safe and effective therapy for the treatment of asthma.
5. Butterbur is an effective preventive treatment for migraine.
6. Butterbur is as effective as fexofenadine in attenuating nasal symptoms in patients with perennial allergic rhinitis.
7. Butterbur extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice.
8. Butterbur's anti-leukotriene activity may be responsible for its beneficial effect on gastrointestinal ulcers.
9. Acupuncture and supplementation with various nutrients and herbs [Butterbur, Coenzyme Q10, Ginkgo biloba , Magnesium, and Riboflavin (Vitamin B-2)] may have therapeutic value in preventing migraines.
10. Butterbur (P. hybridus) exhibits anti-inflammatory activity in rat microglial (brain) cells.
11. Elimination of 'dietary triggers' and the inclusion of a number of natural substances [Alpha-Lipoic Acid, Butterbur, Coenzyme Q10, Feverfew, Magnesium, Riboflavin (Vitamin B-2)] may prevent migraines.
12. S-isopetasin, a compound found in Butterbur, may be beneficial as a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma.
13. A compound found within Butterbur has significant anti-angiogenic activity.
14. Butterbur contains compounds that inhibit peptido-leukotrienes, contributing to the plant's vasorelaxant, gastroprotective and spasmolytic activities.
15. Butterbur is effective for the treatment for intermittent allergic rhinitis symptoms and is well tolerated.